Sunday, April 5, 2020
Sleep Cycle Essay Example
Sleep Cycle Essay Its natural to blame sleep problems on stress or physical changes that come with age. But many cases of either sleeplessness or poor sleep are caused by a handful of specific problems, most of them fixable with lifestyle changes or the help of a doctor. Here, five little-known causes of sleep problems and what to do about them. 1. Light How it disrupts sleep: You probably already know that when you stay up late under bright lights, you interrupt your bodys natural sleep-wake cycle, because light tricks your brain into remaining in daylight mode. Less well known is that the light from computer screens and iPads shining directly into your eyes at close range is especially troublesome. Why? Part of the problem is that the light from these devices is at the blue end of the spectrum, which scientists believe is particularly disruptive to circadian rhythms. Blue light, although common during the day, doesnt occur naturally during the evening. Similarly, light shining in your eyes while you sleep even very small amounts coming from, say, a lighted clock makes your brain think its morning and emerge out of deep sleep. Darkness triggers production of the hormone melatonin, the hormone that triggers sleepiness and the onset of sleep. Light prevents this release or shuts it off. The evidence: Studies have long shown that shift workers and those who work late at night have poorer sleep and higher incidences of certain conditions associated with lack of sleep than those who regularly sleep eight or nine hours at night. A recent study published in Cancer Causes amp; Control, for example, found that the countries generating the most light at night have the highest incidence of breast cancer. We will write a custom essay sample on Sleep Cycle specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Sleep Cycle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Sleep Cycle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer And studies at the Light Research Center at Thomas Jefferson University in Philadelphia have found that the use of computers, lighted readers, and TVs at close range is tied to a higher incidence of sleeplessness. Whos at risk: Everyone exposed to light shortly before bed or during sleep. Light is also bad for hearts, which need deep sleep to recharge. Surprising fact: Every year theres a spike in the number of heart attacks just after the start of daylight savings time in the spring. What to do: Dim the lights and turn off all lighted screens at least an hour before bed. If you use a reading light, make sure its not any brighter than necessary and doesnt shine in your eyes. Do a light police room check: Are there streetlights outside your windows? Use blackout curtains or shades and make sure they fit the windows tightly so no light seeps in around the edge. Charge laptops, phones, cameras, and other devices in another room. Use an alarm clock without a lighted dial, or turn it to face the wall. Keep a flashlight next to your bed and use it whenever you have to get up to use the bathroom or let the dog out and be careful to point it away from yourself so you dont look into the beam. Dont turn on an overhead light, and never use nightlights. If you must use a laptop, turn down the screen brightness as low as you can tolerate and prop the laptop as far away from you as your typing arms will reach. If you love eReaders, try a Kindle or other device with a screen thats not backlit. 2. Pain How it disrupts sleep: Just about any kind of pain signals sent by the brain jaw pain, headaches, back pain, or arthritis, for example disrupt sleep, lifting you from the deep, restful REM cycle into lighter sleep or causing you to sleep fitfully and partially wake up over and over, which experts call microarousals. The evidence: Surveys of chronic pain sufferers reveal that between 60 and 90 percent sleep poorly. But many dont realize that their pain is the cause of their poor sleep. This can become a vicious cycle, says Thomas Roth of the Sleep Disorders and Research Center at the Henry Ford Hospital in Detroit, because even partial sleep disruptions can increase sensitivity to pain. In other words, even mild pain causes poor sleep, which in turn leads to more pain. Whos at risk: Anyone who suffers chronically painful conditions such as arthritis, back or neck pain, jaw alignment problems, dental pain, fibromyalgia, headaches, or any other type of chronic pain. Note: The p ain doesnt need to be severe; studies show that even mild pain disrupts sleep. According to Roth, frequent microarousals can occur throughout the night without your being aware of them. The result is that you never attain deep REM cycle sleep and wake up feeling tired and grumpy, but you dont know why. What to do: Take steps to treat your pain proactively. Using over-the-counter pain relief is a start, but its always best to consult with a doctor and develop a comprehensive pain-relief program. For example, you may need physical therapy to combat back and neck pain, or migraine medication if your frequent headaches might be migraines. If bruxism (teeth grinding) or jaw clenching is leading to jaw pain, a mouth guard is often the solution. 3. Disrupted breathing How it disrupts sleep: When oxygen flow to the brain is interrupted, your brain sends a warning signal that wakes you up either fully or partially, causing fitful sleep or preventing deep, restful sleep. The result: You wake feeling like you didnt sleep well, even if you were out for nine hours straight. The best known version of this is apnea, which is a complete stoppage of breathing. A much more common and less recognized problem is upper airway resistance syndrome, or UARS. In UARS, structural blockages somewhere in the airway nasal congestion, your tongue falling back and blocking the back of the throat, or just having a smaller airway to begin with begin to interfere with the flow of air. What happens is that you wake up over and over again without knowing it, but the sleep interruptions last only a few seconds, too short to be detected by a standard sleep apnea test. The evidence: Even subtle levels of restricted breathing can lead to deep brain stimulation and arousals that prevent your ability to stay in deep sleep, says otolaryngologist Steven Park, an otolaryngologist and author of Sleep, Interrupted: A Physician Reveals the #1 Reason Why So Many of Us Are Sick and Tired. You dont realize youre waking up, but your brain wakes up, so its now in a light sleep. We see people who are waking up 100 times a night. Whos at risk: People who breathe through their mouths or have chronic congestion, such as from asthma or allergies. If you sleep more poorly on your back, this can be a sign of UARS, because when you sleep on your back your tongue is more likely to sink back and block the entrance to your throat. If you have a narrow face, a thin neck, or had extensive orthodontic work to correct a crowded jaw, youre likely to be at particular risk for UARS, says Park. What to do: Start with some self-tests. Try using pillows to keep yourself on your side, or put a tennis ball in the back pocket of pajama bottoms, so you cant sleep on your back. If your nose often feels stuffed up, you might find relief with breathing strips, available at the drugstore. Another option is to try is a device designed to hold the nostrils open; brand names include Nozovent and Breathe with Eez. A saline nasal spray works for many people. If you have congestion due to seasonal allergies, try an antihistamine. (But if you take one that can act as a stimulant, such as Claritin or Sudafed, dont take it too close to bedtime. ) If none of these help, ask your doctor to refer you to an ear, nose, and throat (ENT) specialist, who can evaluate whether youre a candidate for Continuous Positive Airway Pressure (CPAP), a nasal mask that delivers air directly through your airways. An ENT can also determine whether tongue position is causing your UARS, in which case a dental device that pushes the jaw and tongue forward can help. For many people, losing a few pounds can be the ticket to better sleep, since excess weight is linked to all kinds of breathing problems, including UARS, snoring, and sleep apnea. 4. Medications How they disrupt sleep: Medications sometimes have side effects that trigger sleeplessness or interfere with deep sleep. Most common culprits: asthma medications, corticosteroids, blood pressure medications, and antidepressants. Also, many ingredients in common medications act as stimulants. They may cause jitteriness during the day and trigger sleeplessness or prevent deep sleep at night. Example: Bronchodilators like albuterol and salmeterol, commonly used to treat asthma, bronchitis, and COPD, can amp you up and interfere with sleep, yet patients are often directed to use them at the end of the day. Other common medications that can interfere with sleep include SSRIs, such as Prozac and Paxil, and beta-blockers taken for high blood pressure and heart disease. Sometimes medications sabotage your sleep indirectly. Diuretics, for example, can interfere with sleep by causing you to use the bathroom at night. Tagamet (generic name cimetidine), taken to control reflux and ulcers, can cause sleeplessness, especially when combined with caffeine or other medications. Like many side effects, sleeplessness from medications can affect some people but not others; Propecia, used to treat hair loss, and the antihistamine loratadine (brand name Claritin) are both known to cause sleeplessness in a percentage of those who take them. Some people react to opioid pain medications with rebound sleeplessness, feeling sleepy at first but then waking up and being unable to get back to sleep. The evidence: Although every medication is tested for side effects during the FDA approval process, in many cases evidence of side effects mounts over time as a drug enters more widespread use. Albuterol has been widely reported to cause restlessness, nervousness, and sleeplessness. An article in the European Journal of Clinical Pharmacology also found that beta-blockers interfere with melatonin release. Recent studies have found that Prozac, Zoloft, Celexa, and other SSRIs affect sleep in a significant number of patients. If youre using an antidepressant, be sure to talk to your psychiatrist about any possible sleep problems and ask about alternative antidepressants if this is an issue. Whos at risk: Those taking regular medication for a chronic condition such as asthma, depression, high blood pressure, or pain. A medication that you take once is less likely to cause an ongoing sleep issue because you take it for a short period of time and are more likely to notice the side effect. When you have a chronic condition, youre more likely to attribute any sleep problems to the condition rather than the treatment. What to do: Any time youre prescribed a new medication, ask the doctor to discuss in detail all side effects you should be alert to. Its always a good idea to ask both the doctor and the pharmacist, How will this medication affect my sleep? Because some medications cause sleepiness, some interfere with sleep, and some do both, asking the question in an open-ended way will get you the most information. 5. Depression How it disrupts sleep: Fatigue is one of the most prevalent symptoms of depression, yet many people dont realize how closely related depression and poor sleep can be. Depression wreaks havoc with your natural biological rhythms; many people with depression have trouble getting out of bed in the morning, and they oversleep or get fatigued and nap during the day. Yet their sleep is fitful and of poor quality, so despite spending more hours ostensibly sleeping or trying to sleep, they dont feel well rested. Then at night, depression sufferers often have trouble maintaining a regular bedtime routine. Having slept late in the morning or napped late in the day, they may not feel sleepy. Anxiety, which often accompanies depression, may cause excessive late-night worry that contributes to sleeplessness. The evidence: Because the relationship between depression and insomnia is a chicken-and-egg cycle, experts have studied it from both directions. Psychological studies have found that a high proportion of those with depression suffer from either sleeplessness or disrupted sleep, and a recent study by the University of Maryland found that 40 to 60 percent of people Sleep Cycle Essay Example Sleep Cycle Essay Its natural to blame sleep problems on stress or physical changes that come with age. But many cases of either sleeplessness or poor sleep are caused by a handful of specific problems, most of them fixable with lifestyle changes or the help of a doctor. Here, five little-known causes of sleep problems and what to do about them. 1. Light How it disrupts sleep: You probably already know that when you stay up late under bright lights, you interrupt your bodys natural sleep-wake cycle, because light tricks your brain into remaining in daylight mode. Less well known is that the light from computer screens and iPads shining directly into your eyes at close range is especially troublesome. Why? Part of the problem is that the light from these devices is at the blue end of the spectrum, which scientists believe is particularly disruptive to circadian rhythms. Blue light, although common during the day, doesnt occur naturally during the evening. Similarly, light shining in your eyes while you sleep even very small amounts coming from, say, a lighted clock makes your brain think its morning and emerge out of deep sleep. Darkness triggers production of the hormone melatonin, the hormone that triggers sleepiness and the onset of sleep. Light prevents this release or shuts it off. The evidence: Studies have long shown that shift workers and those who work late at night have poorer sleep and higher incidences of certain conditions associated with lack of sleep than those who regularly sleep eight or nine hours at night. A recent study published in Cancer Causes amp; Control, for example, found that the countries generating the most light at night have the highest incidence of breast cancer. We will write a custom essay sample on Sleep Cycle specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Sleep Cycle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Sleep Cycle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer And studies at the Light Research Center at Thomas Jefferson University in Philadelphia have found that the use of computers, lighted readers, and TVs at close range is tied to a higher incidence of sleeplessness. Whos at risk: Everyone exposed to light shortly before bed or during sleep. Light is also bad for hearts, which need deep sleep to recharge. Surprising fact: Every year theres a spike in the number of heart attacks just after the start of daylight savings time in the spring. What to do: Dim the lights and turn off all lighted screens at least an hour before bed. If you use a reading light, make sure its not any brighter than necessary and doesnt shine in your eyes. Do a light police room check: Are there streetlights outside your windows? Use blackout curtains or shades and make sure they fit the windows tightly so no light seeps in around the edge. Charge laptops, phones, cameras, and other devices in another room. Use an alarm clock without a lighted dial, or turn it to face the wall. Keep a flashlight next to your bed and use it whenever you have to get up to use the bathroom or let the dog out and be careful to point it away from yourself so you dont look into the beam. Dont turn on an overhead light, and never use nightlights. If you must use a laptop, turn down the screen brightness as low as you can tolerate and prop the laptop as far away from you as your typing arms will reach. If you love eReaders, try a Kindle or other device with a screen thats not backlit. 2. Pain How it disrupts sleep: Just about any kind of pain signals sent by the brain jaw pain, headaches, back pain, or arthritis, for example disrupt sleep, lifting you from the deep, restful REM cycle into lighter sleep or causing you to sleep fitfully and partially wake up over and over, which experts call microarousals. The evidence: Surveys of chronic pain sufferers reveal that between 60 and 90 percent sleep poorly. But many dont realize that their pain is the cause of their poor sleep. This can become a vicious cycle, says Thomas Roth of the Sleep Disorders and Research Center at the Henry Ford Hospital in Detroit, because even partial sleep disruptions can increase sensitivity to pain. In other words, even mild pain causes poor sleep, which in turn leads to more pain. Whos at risk: Anyone who suffers chronically painful conditions such as arthritis, back or neck pain, jaw alignment problems, dental pain, fibromyalgia, headaches, or any other type of chronic pain. Note: The p ain doesnt need to be severe; studies show that even mild pain disrupts sleep. According to Roth, frequent microarousals can occur throughout the night without your being aware of them. The result is that you never attain deep REM cycle sleep and wake up feeling tired and grumpy, but you dont know why. What to do: Take steps to treat your pain proactively. Using over-the-counter pain relief is a start, but its always best to consult with a doctor and develop a comprehensive pain-relief program. For example, you may need physical therapy to combat back and neck pain, or migraine medication if your frequent headaches might be migraines. If bruxism (teeth grinding) or jaw clenching is leading to jaw pain, a mouth guard is often the solution. 3. Disrupted breathing How it disrupts sleep: When oxygen flow to the brain is interrupted, your brain sends a warning signal that wakes you up either fully or partially, causing fitful sleep or preventing deep, restful sleep. The result: You wake feeling like you didnt sleep well, even if you were out for nine hours straight. The best known version of this is apnea, which is a complete stoppage of breathing. A much more common and less recognized problem is upper airway resistance syndrome, or UARS. In UARS, structural blockages somewhere in the airway nasal congestion, your tongue falling back and blocking the back of the throat, or just having a smaller airway to begin with begin to interfere with the flow of air. What happens is that you wake up over and over again without knowing it, but the sleep interruptions last only a few seconds, too short to be detected by a standard sleep apnea test. The evidence: Even subtle levels of restricted breathing can lead to deep brain stimulation and arousals that prevent your ability to stay in deep sleep, says otolaryngologist Steven Park, an otolaryngologist and author of Sleep, Interrupted: A Physician Reveals the #1 Reason Why So Many of Us Are Sick and Tired. You dont realize youre waking up, but your brain wakes up, so its now in a light sleep. We see people who are waking up 100 times a night. Whos at risk: People who breathe through their mouths or have chronic congestion, such as from asthma or allergies. If you sleep more poorly on your back, this can be a sign of UARS, because when you sleep on your back your tongue is more likely to sink back and block the entrance to your throat. If you have a narrow face, a thin neck, or had extensive orthodontic work to correct a crowded jaw, youre likely to be at particular risk for UARS, says Park. What to do: Start with some self-tests. Try using pillows to keep yourself on your side, or put a tennis ball in the back pocket of pajama bottoms, so you cant sleep on your back. If your nose often feels stuffed up, you might find relief with breathing strips, available at the drugstore. Another option is to try is a device designed to hold the nostrils open; brand names include Nozovent and Breathe with Eez. A saline nasal spray works for many people. If you have congestion due to seasonal allergies, try an antihistamine. (But if you take one that can act as a stimulant, such as Claritin or Sudafed, dont take it too close to bedtime. ) If none of these help, ask your doctor to refer you to an ear, nose, and throat (ENT) specialist, who can evaluate whether youre a candidate for Continuous Positive Airway Pressure (CPAP), a nasal mask that delivers air directly through your airways. An ENT can also determine whether tongue position is causing your UARS, in which case a dental device that pushes the jaw and tongue forward can help. For many people, losing a few pounds can be the ticket to better sleep, since excess weight is linked to all kinds of breathing problems, including UARS, snoring, and sleep apnea. 4. Medications How they disrupt sleep: Medications sometimes have side effects that trigger sleeplessness or interfere with deep sleep. Most common culprits: asthma medications, corticosteroids, blood pressure medications, and antidepressants. Also, many ingredients in common medications act as stimulants. They may cause jitteriness during the day and trigger sleeplessness or prevent deep sleep at night. Example: Bronchodilators like albuterol and salmeterol, commonly used to treat asthma, bronchitis, and COPD, can amp you up and interfere with sleep, yet patients are often directed to use them at the end of the day. Other common medications that can interfere with sleep include SSRIs, such as Prozac and Paxil, and beta-blockers taken for high blood pressure and heart disease. Sometimes medications sabotage your sleep indirectly. Diuretics, for example, can interfere with sleep by causing you to use the bathroom at night. Tagamet (generic name cimetidine), taken to control reflux and ulcers, can cause sleeplessness, especially when combined with caffeine or other medications. Like many side effects, sleeplessness from medications can affect some people but not others; Propecia, used to treat hair loss, and the antihistamine loratadine (brand name Claritin) are both known to cause sleeplessness in a percentage of those who take them. Some people react to opioid pain medications with rebound sleeplessness, feeling sleepy at first but then waking up and being unable to get back to sleep. The evidence: Although every medication is tested for side effects during the FDA approval process, in many cases evidence of side effects mounts over time as a drug enters more widespread use. Albuterol has been widely reported to cause restlessness, nervousness, and sleeplessness. An article in the European Journal of Clinical Pharmacology also found that beta-blockers interfere with melatonin release. Recent studies have found that Prozac, Zoloft, Celexa, and other SSRIs affect sleep in a significant number of patients. If youre using an antidepressant, be sure to talk to your psychiatrist about any possible sleep problems and ask about alternative antidepressants if this is an issue. Whos at risk: Those taking regular medication for a chronic condition such as asthma, depression, high blood pressure, or pain. A medication that you take once is less likely to cause an ongoing sleep issue because you take it for a short period of time and are more likely to notice the side effect. When you have a chronic condition, youre more likely to attribute any sleep problems to the condition rather than the treatment. What to do: Any time youre prescribed a new medication, ask the doctor to discuss in detail all side effects you should be alert to. Its always a good idea to ask both the doctor and the pharmacist, How will this medication affect my sleep? Because some medications cause sleepiness, some interfere with sleep, and some do both, asking the question in an open-ended way will get you the most information. 5. Depression How it disrupts sleep: Fatigue is one of the most prevalent symptoms of depression, yet many people dont realize how closely related depression and poor sleep can be. Depression wreaks havoc with your natural biological rhythms; many people with depression have trouble getting out of bed in the morning, and they oversleep or get fatigued and nap during the day. Yet their sleep is fitful and of poor quality, so despite spending more hours ostensibly sleeping or trying to sleep, they dont feel well rested. Then at night, depression sufferers often have trouble maintaining a regular bedtime routine. Having slept late in the morning or napped late in the day, they may not feel sleepy. Anxiety, which often accompanies depression, may cause excessive late-night worry that contributes to sleeplessness. The evidence: Because the relationship between depression and insomnia is a chicken-and-egg cycle, experts have studied it from both directions. Psychological studies have found that a high proportion of those with depression suffer from either sleeplessness or disrupted sleep, and a recent study by the University of Maryland found that 40 to 60 percent of people
Sunday, March 8, 2020
Chem lab Essay
Chem lab Essay Chem lab Essay Results: Part A: 3. 41 mL of HCl was added to 2.01 g of sodium benzoate solution and a thick solution formed with a white precipitate. After the pH of the solution reached 2, the solution with precipitate was separated by vacuum filtration and dried. After the first drying period the mass of the watch glass and solid was 27.50 g. After the second drying, the solid and watch glass weighed 27.38 g. A constant mass was reached after the second drying as the change in mass was 0.44% indicating a change in mass less that 0.5%. The final mass of the recovered solid was 0.97 g, which in comparison to the theoretical yield of 1.25 g showed a 77.6% yield. Melting point of the recovered solid was also determined to be 118.8-122.8 Ã °C, which shows there may have been some impurity in the solid. Part B: A -10-260 Ã °C thermometer was calibrated using 3 calibration points. The freezing point mark was calibrated using crushed ice and distilled water and a final temperature of 0.15Ã °C was recorded with a -0.15Ã °C calculated correction factor (see Table 1). For the boiling point, distilled water was boiled and the thermometer was placed in the vapour and a temperature of 102.1Ã °C was recorded. The correction factor was calculated to be -2.2 Ã °C, taking into account the atmospheric pressure of 757.4 mm Hg. For the 3rd calibration point the melting point of a sample of succinic acid was determined using a melting point apparatus. The melting point range was determined to be 185.4-189.2Ã °C, giving an average melting point of 187.3Ã °C with a correction factor of 0.70Ã °C. See Figure 1. Thermometer Calibration Graph for a plot of the temperatures recorded vs. their correction factors. Discussion: Part A: Sodium benzoate is used to preserve certain foods against bacteria, yeasts and molds and is used to prolong their shelf life. This compound, when ingested has the potential to mix with stomach acid and undergo a chemical reaction. In a lab, sodium benzoate can be combined with hydrochloric acid (HCl) to simulate the stomach environment. The purpose of this experiment is to determine when these two substances are combined, whether a new substance will be formed. It was predicted that a new substance would form from the combination of sodium benzoate and HCl because when combined, a reaction takes place where protons will transfer from the acid (HCl) to the base (sodium benzoate) and will form benzoic acid, which being water insoluble, will precipitate from the solution. If the pH is low enough, this reaction should occur and since HCl is a strong acid, it is predicted this will occur. In the lab, when 2.01 g of sodium benzoate solution was combined with 3.41 mL HCl (which was when a pH of 2 was reached, similar to the pH of stomach acid), a precipitate did indeed form. 0.97 g of solid was recovered and a melting point range was determined to be 118.8-122.8Ã °C, which supported the formation of benzoic acid. In conclusion, the lab experiment showed the formation of a new substance, which supported the initial hypothesis statement. The combination of sodium benzoate with HCl forms benzoic acid, a new substance, which may or may not have heath effects on those ingesting sodium benzoate as a preservative in foods. Part B: Lab thermometers differ in accuracy and therefore need to be calibrated. Three points were used to calibrate a thermometer including freezing point, boiling point and melting point. The temperatures measured were compared to literature values and a correction factor for the thermometer was determined accounting for any errors in thermometer temperature measurement. These points were plotted onto a graph so that future temperatures taken by the same thermometer can be corrected according to the determined correction factors from the thermometer calibration. For the freezing point a temperature of 0.15Ã °C was measured, which gave a correction factor of -0.15 in comparison to the literature value of the freezing
Friday, February 21, 2020
Market rate of return Assignment Example | Topics and Well Written Essays - 750 words
Market rate of return - Assignment Example If it is observed that the returns are consistently below the SML line, it will mean that the stock is expected to rise, while if the returns are seen to be consistently above the line, then it will mean that the stock is due for a drop. Graphing the SML for a particular stock requires a stock with a beta that is higher than 1 and this usually outperforms the market, while a beta that is less than 1 implies that it underperforms the market (Shanken, 56). The y-intercept of the SML is equal to risk-free rate. The SML slope is equal to market risk premium and it usually reflects the return trade of a given time. Beta is termed as non-diversifiable or systematic risk. Basing on the generated regression line the equation created is=8.375x-0.166 Going by beta values, the security market line indicates that the relationship between return and risk is linear for the individual securities. For instance, increased return= increased risk. Essentially it indicates what return someone needs to e arn on an investment for it to be worth taking, and this is seen to increase with the investment riskiness. The Security Market Line formula is as below: Required Return = Risk Free Rate + (Beta x [Market Return - Risk Free Rate]) Calculate 95% confidence intervals for the slope and y-intercept. SUMMARY OUTPUT Regression Statistics Multiple R 0.997314 R Square 0.994636 Adjusted R Square 0.992848 Standard Error 0.005276 Observations 5 ANOVA Ã df SS MS F Significance F Regression 1 0.015486 0.015486 556.2975 0.000167 Residual 3 8.35E-05 2.78E-05 Total 4 0.01557 Ã Ã Ã Ã Coefficients Standard Error t Stat P-value Lower 95% Upper 95% Lower 95.0% Upper 95.0% Intercept 0.020428 0.004799 4.256403 0.023776 0.005154 0.035702 0.005154 0.035702 X Variable 1 0.118761 0.005035 23.58596 0.000167 0.102737 0.134786 0.102737 0.134786 RESIDUAL OUTPUT Observation Predicted Y Residuals 1 0.04418 0.00582 2 0.079809 -0.00481 3 0.109499 -0.0045 4 0.162942 0.002058 5 0.19857 0.00143 Look up t he current return on one-year Treasury bills/notes as your risk-free rate. Two good sources. In your report, please state your source and the date used. http://fxtrade.oanda.com/analysis/economic-indicators/united-states/rates/yield-curve Date used; November 29, 2013 My risk free rate is 0.05 Given the current risk-free rate, is the regression estimate of your risk-free rate match the actual current risk-free rate? Use confidence intervals to help answer this question. Basing on the confidence interval calculation above, the regression estimate of my risk free rate does not match the actual current risk-free rate because it falls outside the interval or range of 0.10273 and 0.13478 What is the current expected market rate of return (based on your regression)? Basing on my regression, the current expected market rate of return is as below; Using the equation generated from the regression; Y=8.375x-0.166 The current expected market rate of return is equal to X Therefore X=(y+0.166)/8. 375 But we are given Y which is 0.05. The X will now be (0.05+0.166)/8.375=0.02579 Therefore, the current expected market rate of return is 0.02579 Works Cited Shanken, J.On the Estimation of Beta-Pricing Models,"Review of Financial Studies, 5(1), 1{33,1992. Print Shanken, J.,and G.
Wednesday, February 5, 2020
United States And European Union Relations Research Paper
United States And European Union Relations - Research Paper Example Concurrently, the EU established the European Climate Change Programme with the intent of ââ¬Å"identifying the most environmental-friendly and cost-effective ways to enable the EU to meet its target under the Kyoto Protocol.â⬠The Kyoto Protocol is an international agreement bridged to the United Nations Framework Convention on Climate Change. Its main attribute is that it sets binding goals for 37 developed countries and the European countries for reducing greenhouse gas (GHG) emissions. The European Commission issued its schemes for a new energy policy for Europe. This represents the EUââ¬â¢s attempt to align its energy and climate policies. Typified as setting the pace for a ââ¬Å"new global industrial revolutionâ⬠, it asserts to commence the process of delivering a low carbon economy for Europe. However, the Commission needs to improve and expand the EUETS because of some limitations and to address criticisms. US and EU views on how to embark upon global climate c hange have been characterized by widely conflicting opinions on the significance of technology, the economic costs, the role of developing countries and the nature of importance of binding multilateral diminutions targets with or without trading means. However, with the enforcement of the Kyoto Protocol, and the recognition by the Kyoto Parties that medium to longer-term targets is likely to be complex to achieve than the previous commitment period Kyoto targets, the chance to move the pursuit of climate change agenda has arisen.
Tuesday, January 28, 2020
Arguments Of Placebo Effect Health And Social Care Essay
Arguments Of Placebo Effect Health And Social Care Essay The placebo effect may be described as a phenomenon where the symptom of a patient may be modified by ineffective treatment. Essentially the patient has been seen to receive some form of treatment that he or she believes will work. This is a psychological response that can reduce stress and panic thereby leaving the bodys true immune system with an improved chance of working. Placebos are not a cure but merely help to place the patient in a more relaxed and receptive state for treatment. In this regard all medicines essentially provide what is known as the placebo effect. In general terms the placebo has a positive impact if managed by physicians in a proper and responsible way. This is because stress and anxiety are known to affect the body in an adverse manner and possibly make the symptoms worse. Researchers have found that large dummy placebo pills that are coloured seem to stimulate a more positive response from the patients. The important point to emphasise is that the placebo effect is practiced in all medicines and whilst some consider it to be a bogus form of treatment, nevertheless, it accomplishes more good than harm. Counter arguments state that the feel good generation is purposely misleading and could create more serious conditions. The argument is somewhat flawed as very rarely is it ever used as a standalone form of treatment but more a precursor to getting a patient stabilized in a relaxed and more receptive state in order to receive proper medical attention. The arguments of the placebo effect Those arguing against the use of the placebos normally present the following arguments: [1] Introduction of the Nocebo effect whereby patients state that they experience side effects from the in ineffective treatment [placebo]. In most cases this is restricted to clinical trials where placebos are used to test against real medicines. [2] The placebo response of a pain reduction may obscure the real disease and lead towards misleading information to the physician and thus return an incorrect diagnosis of the problem. This can be serious as the wrong course of corrective treatment may be prescribed [3] the illusion effect where the patient is led to believe that the bogus remedy may have worked. This in turn may result in an incorrect or wrong course of treatment to deal with the problem. The medical journal The Lancet provided on an article that stated a new analysis of 110 placebo-controlled randomized trials of homeopathy, indicated there is no evidence that homeopathic tablets perform any better than placebos (Goldacre 2006)à [1]à . Modern medicine has moved towards better patient relationships keeping the patient informed and moved away from the old paternalistic placebo doctrine. Most doctors are uncomfortable with dishonesty and perhaps this is one of the key distinctions against that of the homeopathy practitioners. Adam Harrington stated in Hoboken that the placebo is much more ado about nothing the answer is NO because of the powerful therapeutic effects and YES because of the faddish exaggerations about placebo power. (Harrington 1999). The term placebo is Latin and originated from the Catholic vespers for the dead and translated means I shall please. They emanate from the early medical practices where medical practitioners were unable to diagnose a specific illness and used a placebo essentially to buy time in order to allow additional medical investigations to take place. It was Arthur Shapiroà [2]à who reminded everyone in the 1960s that the physicians themselves were important placebos in their own right i.e. people were comforted by the fact of having an experienced medical practitioner take control of their medical issues. Positive claims for placebos have been made by Dr. Robert Buchmanà [3]à and Karl Salsbugh they seem to have effect on almost every symptom known to mankind, whereas Arthur Shapiro was much more sceptical stating placebos could have a permanent effect on medical disorders. (Evans 2004) One of the most convincing positive arguments for placebos resulted from the work of Dr. Henry Beecherà [4]à who was the American anaesthetist who treated US soldiers in a field hospital in World War 2. In one instance he was treating a soldier with bad injuries and was considering morphine as a pain killer but he was concerned about cardio vascular shock. Instead he put the soldier on saline solution and the result was the patient settled down, he felt less pain and the reaction was similar to morphine. It seemed that salt water could be as effective as morphing considered one of the most powerful painkillers at the disposed of the medical practitioners. Beecher later repeated the trick with the same results and after the war returned to Harvard University to continue his research. Similar studies were being carried out at Cornell University. The subsequent studies carried out by Beecher, gold and lasagne change the way the medical profession viewed placebos and by the mid-1950s doctors were thinking of this as their longer a fraudulent practice. (Evans 2004) Figure : Total Drug Concept by ClaridgeThe complementary practitioners of alternative medicines have advocated that mainstream medicine should become more inclusive and doctors need to incorporate some of these methods into the overall approach to healing. The placebo should no longer be considered as a fake treatment but used where it may influence possible positive outcome on patient care. A model developed by Claridge (Peters 2001). In 1970 required a useful insight into close examination of the placebo effect [Fig 1 refers]. Here he separated the drug out into its very opponents; [1] the drug itself color, shape, form, brand and attributes [2] the prescriber attitude, beliefs, competence, and authority. [3] The recipient the psychological side suggested intelligence, personality etc. [4] selling and clinical side hope, clinic, hospital [physical settings]. Hence the doors former placebo is that so these items without the pharm logical presence of the drug. The concept of beli ef is considered a vital component towards a positive outcome of all forms of medical treatment i.e. Belief in the success of the treatment towards a positive outcome and the expectations in the efficiency of that treatment. Belief lies very central to the persuasive ultimate for the use of placebos. The fact that placebos act on the mind creates an important psychological consideration in their applied use in medicine. Hence more studies in the use of the linkage to the neural system may be appropriate. The US government are taking placebos more seriously and recently the US Food and Drug Agency requires that all new drugs undergo a double-blind, placebo control trial. (Edin 2010). These testing different patient responses to the new drug with the controlled drug or placebo. Medical practitioners have stated that the placebo effect has already made significant contributions in the treatment of ulcers, postoperative pain, seasickness, headaches, colds, arthritis and hypertension. In the treatment of depression statistics have illustrated as high as 70% of relief has been achieved by the use of placebos. This would suggest that a lot more is going on here than pure deception. The belief concept may well i nfluence the chemical releases within the body that are controlled by functions of the brain. Tests with depressive patients were conducted by doctors using brain scans and where there was an expectation by the patient that the condition would improve there was a marked increase in biological changes to the brain. Hence the biological stimulation of the brain is strongly linked to the potency of placebos. People who have been suffering postoperative pain have reported considerable improvement in pain reduction after a simple saline injection. These analgesic effects suggests suggest some form of reception by the brain; this has been referred to as activation of the endogenous pain-relief system of the brain (Connors W 2007). The brain itself manufactures morphine like substances called endorphins the brain can trigger or send these to those parts of the body experiencing pain. Hence placebos may be able to stimulate this part of the brain in order to enhance that stimulation process . Placebo affects are not limited purely too chemical or drug treatments, they have also been included in both surgery and physiological therapies. A summary of the many literature works on placebos leads towards a number of preliminary conclusions:- [1] A significant number of patient show a therapeutic response from the administration of a placebo [2] There seems to be no uniform practice that sets itself out as a prescribed means of treatment in this area [ 3] It appears that any object with therapeutic intent can invoke similar circumstances [4] The mechanism of the effects remains relatively unknown and the conditions in which it operates are unclear. (Wickramsehera 1988) CONCLUSIONS The advantage that supports the use of placebos are essentially threefold: [1] the mind over matter concept whereby the placebo acts as an assist to the bodys natural defence mechanism [2] the provision of a psychological boost or stimulus to the brain which may prove to be an important contribution to the overall recovery of the patient [3] A support to the central concept of belief which is known to be a major contributing factor towards recovery. The main disadvantages might be summarised as [1] In the area of chronic pain the patient may show an immediate spontaneous improvement and as such give cause to a false diagnosis of the problem [2] The element of deception may provide the patient with false hope or expectations and give rise to medical ethical considerations [3] The patient may provide the Doctor with erroneous information believing that the placebo has resolved the problem. This loses valuable time in the determination of the correct prognosis and could prove serious in certain cases. There is also the strong argument that placebos can become habit forming. One example being the use of valium for strong headaches. These may essentially provide temporary relief but they are certainly not an ongoing solution. It is the unsettling notion that people are getting medical treatment from unqualified practitioners. The concept of non-medically trained people prescribing any form of placebo implies that the patient is ill and as such this can be a powerful message to the patient. The action of medication is not just controlled by the drug companies as the pharmaceutical companies have to undergo extensive clinical trials before they can release a product to the market place. A lot of the controversy with the applied use of placebos is around the use of these in clinical trials. Many consider that the use of these is unethical but it raises the question as to whether the trials could be successful without them Arguments against the use of placebo groups in clinical trials have been based on opinion rather than evidence. Ethical issues have been raised, but these are contentious. (Martin Tramer 1998). The ethical consideration will continue to be debated in the medical profession but the continued use in clinical trials is likely to proceed at least for the foreseeable future In clinical settings where no gold standard treatment exists and where event rates vary widely, trial designs without placebo controls are unlikely to yield sensible results (Martin Tramer 1998). The concept of Doctors saying the placebo is a nuisance variable has equally been contested by the medical profession There has been sharp disagreement on this point, due to the fact that medical literature includes a great deal of testimony that the placebo effect routinely works 30 percent of the time, with Dr. Herbert Benson of Harvard stating that it may work up to 90 percent of the time. (World Research Foundation 2011). 2015
Sunday, January 19, 2020
Global Warming Essay -- Causes and Effects of Climate Change
Pollution in our world is leading to increased global warming. Global warming is a problem that if it doesnââ¬â¢t effect us, it will effect all future generations. Global Warming is a problem that all of us can solve, and it should be solved through the work of our community. Global Warming is caused by the Greenhouse Effect. The Greenhouse effect causes the sunââ¬â¢s rays to come in the earthââ¬â¢s atmosphere, and when it bounces back, more and more of the sunââ¬â¢s rays stay in the Earth, heating up the average global temperature. Greenhouse gasses cause the addition of the Greenhouse Effect. Greenhouse Gasses cause an increase in the Greenhouse Effect. Greenhouse Gasses are created whenever a fossil fuel is burned. It is not the burning of the fossil fuel, but the emissions of the gas from the burning fossil fuel that adds to the Greenhouse Effect. Greenhouse Gasses in this planet are natural, but with added amounts of Greenhouse Gasses, the Greenhouse Effect gets much stronger. There are several simple solutions, but many people donââ¬â¢t care about the environment enough to help stop Global Warming. One Step to stop Global Warming could be to turn off your computers when you finish with them, because computers use electricity, witch is created mostly by the burning of Fossil Fuels. Another Step to control Global Warming could be to use Public Transportation, rather than each person driving around in a car, because each less car reduces the level of oil burned. Another way to stop Global Warming could be to Recycle, because lots of garbage is burned, adding to the Greenhouse Effect. Global Warming is a serious problem, and it needs to be solved, NOW! The global warming hypothesis originated in 1896 when Svante Arrheniu... ... course of geologic time without any assistance from human activity. Says Singer, ââ¬Å"The human component [in recent global warming] is thought to be quite small. . . . The climate cooled between 1940 and 1975, just as industrial activity grew rapidly after WWII. It has been difficult to reconcile this cooling with the observed increases in greenhouse gases.â⬠Singer also argues that temperature observations since 1979 are in dispute: Surface readings with thermometers show a rise of about 0.1 degree C per decade, while data from satellites and balloon-borne radiosondes [miniature transmitters] show no warmingââ¬âwith possible indications of a slight coolingââ¬âin the lower atmosphere between 1979 and 1997. Until the science behind the global warming theory is more settled, Singer and other skeptical scientists advocate placing no limits on the consumption of fossil fuels.
Saturday, January 11, 2020
Balfour vs. Balfour Case Study
Law of contract BALFOUR vs. BALFOUR [1919] 2K. B. 571 TABLE OF CONTENTS 1. LIST OF ABBREVIATIONS 2. LIST OF CASES 3. FACTS OF THE CASE 4. ISSUES INVOLVED 5. CONTENTIONS 6. JUDGMENT 7. LAW POINT 8. BIBLIOGRAPHY LIST OF ABBREVIATIONS I. L. J. : Lord Justice II. AIR : All India Reporter III. QBD : Queenââ¬â¢s Bench Division IV. CBNS : Common Bench Report (New Series) V. AER :All England ReporterVI. CLR : Commonwealth Law Reports LIST OF CASES Cases referred to by the court of appeal in Balfour vs. Balfour: I. Eastland vs. Burchell (1878),3 Q. B. D. 432 II. Jolly vs. Rees (1864),15 C. B. N. S. 628 III. Debenham vs. Mellon (1880),6 App. Cas. 24 Cases having the same law point as Balfour vs. Balfour: I. Rose and Frank Co. vs. Crompton & Bros. Ltd. (1925) A. C. 445 II. Jones vs. Padavatton (1969) All E. R. 616 III. Meritt vs. Meritt (1970) 2 All E. R. 760 IV. S. V. R. Mudaliar vs. Rajababu AIR 1995 SC 1607. Some recent case laws having the same law point:I. Ermogenous v Greek Orthodox Community of SA Inc (2002) 209 CLR 95 Facts Archbishop Ermogenous made a claim for payments he thought due for annual and long service leave from the Greek Orthodox Community. He succeeded at first instance but the Full Court of the Supreme Court of SA found there was no intention to create legal relations between the parties. An appeal was made to the High Court. II. EDMONDSà v LAWSONà (2000) FACTS OF THE CASE After their marriage in August, 1900, the parties went to Ceylon, where the husband had a government post.In November, 1915, the wife came to England together with the husband, who was on leave. they both intended to return to Ceylon . In August,1916,the husbandââ¬â¢s leave expired and he had to return to Ceylon ,but the wife ,on the advice of her doctor ,was to remain in England. On August 8, 1916, when the husband was about to sail, the wife alleged that the parties enter into an oral contract whereby the husband agreed to make an allowance of ? 30 a month. The parti es had not at that time agreed to live apart, but did so subsequently when differences arose between them.An action was taken by the wife against the husband to recover money which she claimed was due to her under the agreement, the alleged consideration for that agreement being a promise by her to support herself without calling upon him. ISSUES INVOLVED * Was there any legally enforceable contract? * Was there any intention to enter into a legal relationship? CONTENTIONS PLAINTIFF: In this case the wife said: ââ¬Å"In august 1916, my husbandââ¬â¢s leave was up . I was suffering from rheumatoid arthritis. My doctor advised my staying in England for some months, and not to go out till Nov. . I booked a passage for next sailing day in September. On august 8 my husband sailed. He gave me a cheque from august 8 to august 31 for 24 pounds, and promised to give me 30 pounds per month till I joined him in Ceylon. â⬠She also showed some letters about which she said: ââ¬Å"My husb and and I wrote the figures together on august 8 and 34 pounds were shown. Afterwards he said 30 pounds. â⬠She wanted to recover money from her husband. DEFENDANT: The lower court entered judgment in favor of the plaintiff and held that the defendantââ¬â¢s promise to send money was enforceable.The court held that Mrs. Balfourââ¬â¢s consent was sufficient consideration to render the contract enforceable and the defendant appealed. JUDGEMENT At first instance, Sargant, J. , who was sitting as an additional judge of the Kingââ¬â¢s Bench Division took into account the points that the wife in this case sued her husband claiming that her husband had agreed to give her an allowance of ? 30 per month which he failed to give, she claimed that there was a binding legal contract and the husband shall in consideration of a promise by the wife pay her the sum of ? 0 a month . Sargant J. held that there was a binding agreement and gave the descion in the favor of the wife after thi s an appeal was filed by the husband. Warrington,L. J. a judge in the court of appeal noted that there was a valid consideration in this case and said that : ââ¬Å"It seems to me on these letters that there was a definite bargain between the husband and the wife under which ,while the husband was in India and in a sufficient position and the wife was in England living separate from him ,she should be paid a definite sum of ? 0 a month ,and that agreement was made when the husband retuned to Ceylon ,and was reaffirmed on at least two occasions after unhappy differences had shown themselves ,at any rate on the part of the husband ,and when it was probable that their separation might last for some time. â⬠Then he proceeded by saying that there was not exactly a valid contract because this agreement continued because of the circumstances which arose and this agreement cannot be termed as a legal contract because the intention to enter into a legal relation is missing.He observed that it was quite plain that no such contract was made in express terms, and there wasnââ¬â¢t any bargain on the part of the wife at all. All that took place was this; the two parties met in a friendly way and discussed what would be necessary for the support of the wife while she was in England,there wasnââ¬â¢t any proof that the wife wanted the sum of ? 30 as a compensation or in the satisfaction of the obligations of the husband towards her to maintain her. He said that ââ¬Å"the husband expressed his intention to make the payment, and he was bound in honour to continue it so long as he was in a position to do so.The wife on the other hand, as far as I can see, made no bargain at all. â⬠He concluded by saying that the judgment made by Sargant, J. , was wrong and the appeal should be allowed. DUKE,L. J. another judge in the court of appeal agreed with Warrington,L. J. and said that the only question in this case is whether the promise of the husband to the wife ,that w hile she was living absent from him he will make her a periodical allowance, is a promise which involves in law consideration on the part of the wife sufficient to convert the promise into an agreement.He said that according to him there wasnââ¬â¢t any legally enforceable contract and the basis of this agreement was the relationship of husband and wife and the proposition that the mutual promises made in the ordinary domestic relationship of husband and wife of necessity gives cause for action on a contract seems to go to the root of the relationship .He concluded by saying ââ¬Å"I think that in point of principle there is no foundation for the claim which is made here ,and I am satisfied on the question of fact that there was no consideration moving from the husband to the wife or promise by the husband to the wife which was sufficient to sustain this action founded merely on contract . In my view ,the appeal must be allowed. â⬠ATKIN,L. J. lso supported the judgment of th e other two judges and said that in the arrangements between husband and wife mutual promises are present but there is no consideration which is necessary for a legally enforceable contract, in addition to this the intention to be attended by legal consequences is also absent. Such cases canââ¬â¢t be sued upon because the parties in the inception of the arrangement never intended that they should be sued upon. He said : ââ¬Å"I think that the parol evidences upon which the contract turns does not establish a contract .I think that the written evidences donââ¬â¢t evidence a contract . For this reason I think that the judgment of the learned judge in the court below was wrong ,and that this appeal should be allowed. LAW POINT The law point in this case is: Intention to create legal relationship. Intention to create legal relations is an essential element for creation of a contract. Intention to create legal relations is defined as an intention to enter a legally binding agreeme nt or contract. It consists of readiness of a party to accept the legal sequences of having entered into an agreement.Intention to create legal relations is a motion of every contracting party must have the necessary intention to enter into a legally binding contract. Promise in the case of social engagements is generally without an intention to create a legal relationship. Such an agreement therefore, cannot be considered to be a contract. Thus an agreement to go for a walk ,to go to a movie, to play some game, or entertain another person with with a dinner, cannot be enforced in a court of law.Sometimes the parties may expressly mention that it is not a formal or legal agreement, whereas in some other cases such an intention could be presumed from their agreement. Under UK law, an agreement supported by consideration is not enough to create a legally binding contract; the parties must also have an intention to create legal relations. Often, the intention to create legal relations is expressly stated by the contracting parties. In other situations, the law will readily imply the intention, because of the nature of the commercial dealings between the parties.Generally it is assumed that in social and domestic type of agreements this type of intention is absent, but parties do intend to create legal relations in commercial agreements. It is assumed that this doctrine was not clearly established until 1919. Alternatively, it can be said that the Doctrine is based upon public policy; that is to say that, as a matter of policy, the law of contract ought not to intervene in domestic situations because the courts would then be swamped by trifling domestic disputes.The test to know the intention of the parties is objective and not subjective merely because the promisor contends that there was no intention to create legal obligation would not exempt him from liability. It may be noted that although in the case of close relationship there may be generally no intention to create legal relationship but there is nothing which prevents these persons from agreeing to be bound by their promises thus if an arrangement clearly shows an intention to create legal relationship the parties become bound thereby.It is still an open question whether in the express provisions in the Indian Contract Act ,1872,the requirement of intention to contract is applicable in India. BIBLIOGRAPHY A. PRIMARY SOURCE [1918-19] All E. R. Rep. B. SECONDARY SOURCE Indian Contract Act ââ¬âR. K. Bangia C. OTHER SOURCES www. indlaw. com www. indiankanoon. org http://www. australiancontractlaw. com
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